This gene is unusual in that its coding sequence is derived almost entirely from a cluster of different Alu repeat sequences. However, the mRNA and the encoded protein have been shown to be expressed in neurons, and overexpressed in brains with Alzheimers disease. In vitro studies also demonstrated that abnormal expression of this gene promoted neuritic sprouting and cell death, associated with dementia in Alzheimers disease. AD7C-NTP是存在于神經(jīng)元中的一種41Kda的蛋白質(zhì),在AD患者腦內(nèi)選擇性升高,和其病理過程相關(guān),AD7C-NTP基因也只在神經(jīng)元表達(dá),AD患者腦脊液中AD7C-NTP表達(dá)升高, AD7C-NTP作為AD早期診斷和確診的生物化學(xué)標(biāo)志正引起越來越多的關(guān)注.
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù)) not yet tested in other applications. optimal dilutions/conceations should be determined by the end user.